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Hydrochlorothiazide manufacturer CAS:58-93-5

Sep 9th, 2022 at 20:43   Biological and Pharmaceutical Chemicals   Wheatley Heights   55 views Reference: O5xe76X1d7r

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Synonyms:
Hydrochlorothiazide
6-Chloro-3,4-Dihydro-(2H)-1,2,4-Benzothiadiazine-7-Sulfonamide 1,1-Dioxide
2H-1,2,4-Benzothiadiazine-7-sulfonamide, 6-chloro-3,4-dihydro-, 1,1-dioxide
Molecular Formula: C7H8ClN3O4S2
Molecular weight:297.73900

Appearance and properties: white crystalline powder
Density: 1.693g/cm3
Boiling point: 577ºC at 760mmHg
Melting point: 273 °C
Flash point: 302.7ºC
Refractive index: 1.632
Stability: Stable. Incompatible with strong oxidizing agents.
Storage conditions: low temperature, ventilated and dry warehouse
Applications: Hydrochlorothiazide (English: Hydrochlorothiazide, referred to as HCTZ, HCT or HZT) is a diuretic. It is usually used to treat high blood pressure and edema caused by fluid accumulation. Other uses include the treatment of diabetes insipidus and renal tubular acidosis. It can also reduce hypercalciuria (English: Hypercalciuria), thereby reducing the risk of kidney stones.


Items of Analysis Standard of Analysis Test Results
Characters Whiteor practically whitecrystalline powder, practically odorless Conforms
Soluble Slightly soluble in water; freely soluble in sodium hydroxide solution, in n-butylamine, and in dimethylformamide; sparingly soluble in methanol; insoluble in ether, in chloroform, and in dilute mineral acids. Conforms
Identification IR,UV Conforms
Loss on drying ≤0.5% 0.1%
Residue on ignition ≤0.1% 0.04%
Chloride ≤0.035% Conforms
Selenium ≤0.003% Conforms
Heavy metals ≤ 0.001% Conforms
Related compounds Benzothiadiazine relatedcompound A ≤ 1.0% 0.4%
Any other impurities≤ 0.5% Conforms
Total other impurities ≤0.9% 0.5%
Organic volatile impurities Meets the requirements Conforms
Assay 98.0~102.0% 100.1%
Conclusion Conforms to USP42


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