FocusHerb Palm Oil Extract Powder 98% Micronized Palmitoylethanolamide PEA

Focusherb Palm Oil Extract Powder 98% Micronized Palmitoylethanolamide Pea - Buy Pea,Palmitoylethanolamide Powder,Palmitoylethanolamide (pea) Product manufacturer and supplier from China, Please contact us by Live Chat on the bottom right.

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FocusHerb Palm Oil Extract Powder 98% Micronized Palmitoylethanolamide PEA

What is Palmitoylethanolamide powder?

Palmitoylethanolamide (PEA), produced in the body, is a natural painkiller ingredient in the endogenous fatty acid amide category and synthesized within your own body. We call it endogenous. Palmitoylethanolamide pea powder is widely applied in sports nutrition supplements and joint health formulas worldwide, especially in the United States, Australia, UK, Canada, and EU countries like the Netherlands, Belgium, and Italy.

Palmitoylethanolamide chemical properties：

The IUPAC name of PEA is N-(2-Hydroxyethyl) hexadecanamide. Raw Palmitoylethanolamide is usually in powder form, with molecule formula and weight as C18H37NO2 and 299.49 respectively. 544-31-0 is Palmitoylethanolamide’s CAS Registry Number and unique chemical identity. Palmitoylethanolamide is practically insoluble in water and poorly soluble in most other aqueous solvents. Therefore, you may find that almost 99% of finished dosage formulations of palmitoylethanolamide are in capsules or soft gels.

Palmitoylethanolamide food sources： Some natural sources are found to contain Palmitoylethanolamide.

You may notice that soy lecithin, soybean, egg yolk, peanut (Arachis hypogaea), and Medicago sativa are among the top food sources. However, the calculating weight unit is ng/g (nanogram/gram). 6700 ng/g is equal to 6.7mg/kilo, meaning that only 6.7mg PEA is in 1 kilo of soybean. The concentration of palmitoylethanolamide in natural foods are too low to meet our daily need. All the market need is bulk Palmitoylethanolamide, high in concentration and low in manufacturing cost. Bio is a bulk supplier of palmitoylethanolamide raw powder. If you have any questions regarding PEA, just feel free to contact us.

Mechanism of action of Palmitoylethanolamide PEA： Palmitoylethanolamide PEA works by affecting various receptors directly or indirectly, such as PPAR-a, CB1, CB2, GPR119, GPR55,etc.

Palmitoylethanolamide PEA powder increases the endogenous levels of AEA (anandamide) and 2-AG(2-arachidonoyl-glycerol) through the inhibition of the activity or expression of FAAH, or via additional unknown mechanisms, which directly activate CB2 and TRPV1 receptors (transient receptor potential vanilloid type-1 channel). PEA, possibly through allosteric modulation of TRPV1 receptors, potentiates the actions of AEA and 2-AG at TRPV1 receptors. PPAR-α and GPR55 are direct receptors. The PPAR-a receptor mediates mood, pain, and neuroinflammation. PEA bound to PPAR-a receptors forms heterodimers with retinoic acid receptors. The dimer acts as a transcription factor promoter of peroxisome proliferator response elements. Activation of PPAR-a increases the production of intracellular neurosteroids, which alters calcium channels and big conductance potassium channels leading to hyperpolarized neurons. This accounts for the antiseizure activity of PEA in animal models. Palmitoylethanolamide blocks the excessive activity of mast cells and glial cells and restores their normal activity. By the way, Palmitoylethanolamide also cuts down the activity of the pro-inflammatory enzyme COX. There are more mechanisms showing how palmitoylethanolamide works (listed at the very bottom of this page.)

Dietary Supplement containing Palmitoylethanolamide: If you check all the nutritional products markets, you’ll find various PEA supplement products available, some in capsules, some in tablets, some even in powder forms; some are in a single ingredient formula, some are blended with other joint health compounds. Below are some typical examples of PEA forms and their respective dose information:

PEA Discomfort Relief:

This Palmitoylethanolamide is in chewable tablet form. One tablet contains 600mg PEA, and the dose is one to two tablets a day, that’s 600mg to 1200mg daily.

PEA-Min

This PEA formula is Palmitoylethanolamide 600mg with 300mg Turmeric Root Extract (95% curcuminoids) per serving. (per day)

Where to buy Palmitoylethanolamide powder? Our company is a professional manufacturer of bulk palmitoylethanolamide powder, and able to ship to every country by courier, by air, by sea, or other means. Be aware that our product is in a raw ingredient product package, and our website has no add to cart function. If you want to buy or purchase a bulk quantity, please contact us directly by email for more details. Our micronized PEA powder has been tested by trusted and authoritative Third-Party Testing labs and organizations on purity, Heavy Metals, Residual Solvents, NMR spectrum, microorganism testing (Microbiology testing) and Oral Acute Toxicity Study of Palmitoylethanolamide The purity (assay) of Palmitoylethanolamide tested by Advanced Botanical Consulting & Testing Inc.(ABC Testing. Inc) is 99.18%

Q1: Are you manufacturer or trading company? A1: We are manufacturer. For some special or rare products, we can also make trade for you. Q2: What certificate does your company have? A3: ISO 9001, Kosher, Halal, EU and USDA certificate are available. Q3: Is the price on Ali page the final price? A3: Not really. Some prices change from time to time and haven’t been updated. The actual price is subject to the salesman''s quotation. Q4: Can I get some sample? A4: Yes, for most low value products, usually 10-20g free sample can be provided. Q5: What''s your MoQ? A5: Our MoQ is flexible, usually 1 kg-10 kg for trial order. Q6: How to start orders or make payments? A6: There are two ways for you to confirm order: 1. Proforma invoice with our company bank details will be sent to you once the order confirmed. Pls arrange payment by TT (wire transfer). 2. Trade assurance order will be drafted for you through our website. Pls confirm and pay through our website (credit card). Q7: How long for production and delivery? A7: Most products we have in stock, lead time: within 1-4 business days after received payment. Customized products further discussed. Q8: What are your delivery methods? A8: Fedex, DHL, By Air, By Sea and the specific line forwarder. Recommend: ≤50kg by DHL/Fedex door to door, it will takes 5-7 days generally. ≤200kg by Air with airport to airport, it will takes 7-9 days generally. ≥200kg by Sea with port to port, it will takes 18-25 days generally. Q9: How about the packing? A9: 1 kg per aluminum foil bag, 20kg per carton, 25kg per drum and OEM package. Q10: Do you accept ODM or OEM service? A10: Sure, we make ODM and OEM services for many customers. Ranges: Soft gel, Capsules, Tablets, Sachet, Granule, Private Label service, etc. Please contact us to design your own brand product. Q11: What is the shelf life for the products? A11: Most products shelf life 24-36 months, meet with COA. Q12: Is there a discount? A12: Of course, welcome to contact us. Price would be different based on different quantity. For bulk quantity, we will have discount for you.