4-Hydroxyacetophenone CAS 99-93-4 China Manufacturer & Supplier
Sep 26th, 2022 at 14:44 Agrochemicals Levittown 50 views Reference: WJxbovJkagw
Location: Levittown
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4-hydroxyacetophenone Cas 99-93-4 China - Buy 4-hydroxyacetophenone Cas 99-93-4,99-93-4,China Product manufacturer and supplier from China, Please contact us by Live Chat on the bottom right.
Essential details
| CAS No.: |
99-93-4 |
| Other Names: |
Hydroxyacetophenone |
| MF: |
C8H8O2 |
| Place of Origin: |
China |
| Type: |
Agrochemical Intermediates, Dyestuff Intermediates, Flavor & Fragrance Intermediates, Syntheses Material Intermediates |
| Purity: |
99% |
| Model Number: | |
| Application: |
Pharmaceutical raw materials |
| Appearance: |
Colorless transparent liquid |
Supply Ability
| Supply Ability | 1000 Metric Ton/Metric Tons per Month |
Packaging & delivery
25K/DRUMQingdao;Shanghai
| Packaging Details | |||||||
| Port | |||||||
| Picture Example: | |||||||
| Lead time: |
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Product Description
Description
4′-Hydroxyacetophenone
4′-Hydroxyacetophenone Quick Details
Chemical Name: 4′-Hydroxyacetophenone
CAS No.: 99-93-4
Molecular Formula: C8H8O2
Chemical Structure:
Molecular weight: 136.15
Appearance: White crystalline solid
4′-Hydroxyacetophenone Properties
| Item | Specifications |
| Appearance | White crystalline solid |
| Solubility | Soluble in Methanol,Insoluble in water |
| Assay(C) | ≥99.9% |
| Phenol | ≤10ppm |
| O-Dichlorobenzene | ≤10ppm |
| Melting Point | 108-110℃ |
| Water(By KF) | ≤0.5% |
4′-Hydroxyacetophenone usage
1. Used in the manufacture of choleretic and other organic synthetic raw materials. Animal experiments show that this product can increase the secretion of bile in rats, and also increase the discharge of solids, bile acid and bilirubin in bile, and also have the same effect on liver damage caused by carbon tetrachloride. Commonly used as an adjunct to cholecystitis and the treatment of acute and chronic jaundice hepatitis, but the application must comply with the doctor’s advice. This product is clinically used for the treatment of hepatitis and has a certain effect on yellowing. Therefore, it is harmful to swallow this product, and the contact is irritating to the eyes, respiratory system and skin.
2. This product is an organic synthesis intermediate used in the production of spices. The main synthesis of a-bromo-p-hydroxyacetophenone is an important intermediate for the synthesis of a selective B l receptor blocker, atenolol.
3. 4′-Hydroxyacetophenone is mainly used as a preservative in cosmetics. Due to its weak molecular activity, high temperature resistance, melting point of 95-97 ° C, and boiling point of 296 ° C, it is widely used in various liquid pharmaceuticals, which can prolong the shelf life of other active ingredients under high temperature conditions. It is currently a high temperature auxiliary active stabilizer in the pharmaceutical industry.
4.4′-Hydroxyacetophenonehas the following characteristics in cosmetics:
1) has a certain anti-corrosion ability;
2) has a strong ability to kill Aspergillus niger;
3) has a certain inhibitory effect on Pseudomonas aeruginosa cells. In addition, it is reported in the literature that it is compounded with 1,2-hexanediol and traditional Chinese medicine composition; the compounded composition has good antiseptic effect, no harm to human skin, and overcomes the current preservative damage to human skin. defect
There are two traditional preparation methods for 4′-Hydroxyacetophenone
(1) Two-step method: firstly, phenol esterification is carried out to form phenol acetate, and then Fries rearrangement reaction is carried out under the action of an anhydrous aluminum trichloride catalyst. For example, Lu Huijie of Zhengzhou University heated with phenol and acetic anhydride to reflux acetic acid, then distilled phenolic ester, then chlorobenzene as solvent, anhydrous AlCl3 as Lewis acid, and phenolic acetate added dropwise, the reaction was aligned and The ortho products (69% and 23%, respectively) have lower yields (Reference: Chemical Reagents, 1993, 15(4): 254).
(2) One-step method: Para- and ortho-products (31.5% and 68.5%, respectively) were obtained by phenol and acetyl chloride under anhydrous AlCl3 catalysis. The method used chlorobenzene as a solvent (Ref: DELogin to View).
The traditional method has more or less a part of the ortho isomers, affecting the yield of 4′-Hydroxyacetophenone, and the use of a large amount of AlCl3 in the reaction process, the direct consequence of this is Post-processing is complicated and environmental pollution is serious.
4′-Hydroxyacetophenone Packaging and Shipping
Fiber drum,25kg
4′-Hydroxyacetophenone Storage
Keep tightly closed in a cool dry place.
Packaging & Shipping
FAQ
Q1: Can I get a sample before placing an order? Reply: Yes, we provide samples, but you need to pay a certain product cost and freight. When we cooperate for a period of time or you are our VIP customer, we will provide free samples when you need them. Q2: what kind of payment method can you use? Reply: Telegraphic transfer, letter of credit or our website Trade Insurance, etc. You can choose one that is convenient for you. Q3: How and when can I get the goods after payment? Reply: For small batch products, they will be delivered to you by international express (DHL, FedEx, TNT, etc.) or by plane. It usually takes 3-5 days to get the goods after delivery. For large quantities of products, it is worthwhile to transport by sea. It takes days to weeks to arrive at the port of destination, depending on where the port is. Q4: Is it possible to use the label or package I specify? Reply: Yes. If necessary, we can use labels or packaging according to your requirements. Q5: What is MOQ? Reply: enerally speaking, the minimum order quantity is 1kg
