4-Chloro-3-(trifluoromethyl)phenyl isocyanate manufacturer CAS:327-78-6
Sep 9th, 2022 at 20:18 Agrochemicals Chickasha 61 views Reference: Wpmbk526ezJLocation: Chickasha
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Chemical Name: 4-Chloro-3-(trifluoromethyl)phenyl isocyanate
CAS.NO: 327-78-6
Synonyms:
4-Chloro-3-(trifluoromethyl)phenyl Isocyanate
Sorafenib intermediates 3
Isocyanic Acid 4-Chloro-3-(trifluoromethyl)phenyl Ester
1-chloro-4-isocyanato-2-trifluoromethylbenzene
3-TRIFLUOROMETHYL-4-CHLORO-PHENYL ISOCYANATE
4-Cl-3CF3-phenyl isocyanate
1-chloro-4-isocyanato-2-(trifluoromethyl)benzene
4-Chloro-3-(trifluoromethyl)phenylisocyanate
Molecular Formula:C8H3ClF3NO
Molecular Weight: 221.56400
Physical and Chemical Properties:
Density: 1.4 g/cm3
Boiling point: 86-90 °C14 mm Hg(lit.)
Melting point: 40-42 °C(lit.)
Flash point: 211 °F
Refractive index: 1.487
Specification:
Appearance: white crystalline
Purity:≥98.0%
water content:≤0.5%
Impurity A≤0.15%
Impurity B≤1.0%
Other single impurity≤0.5%
Total impurities≤2.0%
Packing:
25kg cardboard drum or according to customer specified requirements
Storage:
Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances.
Application:
4-Chloro-3-(trifluoromethyl)phenyl isocyanate is used as a reagent to synthesize pyrimidinylaminobenzene derivatives, compounds that have antiproliferative activity against melanoma cell lines. 4-Chloro-3-(trifluoromethyl)phenyl isocyanate is also used to synthesize α-thymidine analogues that act as antimalarial agents.intermediates of Sorafenib tosylate CAS:475207-59-1.
Items of Analysis | Standard of Analysis | Test Results |
Appearance | White crystal | Conform |
Identification |
IR HPLC |
Conform Conform |
Moisture | ≤0.5% | 0.03% |
Relative Substance | Impurity A≤0.15% | N.D |
Impurity B ≤1.0% | 0.20% | |
Other single impurity ≤0.5% | 0.01% | |
Total impurities ≤2.0% | 0.20% | |
Assay(HPLC) | ≥98.0% | 99.79% |
Conclusion | Conforms to Factory Standard |
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Inno Pharmchem (Pharmaceutical Intermediates Manufacturers in China) is exclusively focusing on the manufacturing of API's Intermediates, such as 4-Chloro-3-(trifluoromethyl)phenyl isocyanate, cas:327-78-6 , 1-chloro-4-isocyanato-2-(trifluoromethyl)benzene and so on. We have helped clients businesses by scaling up its pharmaceutical products through the development of innovative processes and optimizing the production process thus it making it cost-efficient.
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