Wholesale Arbutin 99% 497-76-7 Manufacturer & Supplier

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1.0kg Aluminum foil bagmain port in China

Arbutin

Arbutin is the new aesthetic whitening agent successfully developed in recent years, it is an ideal additive ingredient in functional whitening cosmetics. It can effectively restrain the melanogenesis. After application of the cosmetics which are formulated with certain amount of Arbutin, the senile yellowish brown plaque and pigmentation can evidently be diminished.

Arbutin, (hydroquinone-O-beta-D-glucopyranoside) a naturally occurring -d-glucopyranoside derivative of hydroquinone.Arbutin exerted its effect through a controlled release of hydroquinone by the in vivo hydrolysis of the glycosidic bond. It is reported by various researchers to inhibit the oxidation of L-DOPA catalysed by mushroom tyrosinase. A recent study indicated that arbutin inhibits melanin synthesis by inhibition of tyrosinase activity. This appears to be due to the inhibition of melanosomal tyrosinase activity and Pmel-17 protein at noncytotoxic concentrations rather than the suppression of this enzyme’s synthesis and expression. It also inhibits the maturation of melanosomes, possibly by its reported influence on DHICA (5,6-dihydroxyindole-2-carboxylic acid) polymerase activity. It is thought that the activity of arbutin is driven by the structural homologies that it shares with the substrate tyrosine. It was showed that arbutin inhibits the oxidation of L-tyrosine (monophenolase activity) catalysed by mushroom tyrosinase and that it competes for active binding sites in tyrosinase without influencing the mRNA transcription of tyrosinase or being oxidized. However, arbutin itself was oxidized as a monophenol substrate at an extremely slow rate, and the oxidation was accelerated as soon as catalytic amounts (0.01 mM) of l-3,4- dihydroxyphenylalanine (L-DOPA) became available as a cofactor.

Function:

1. It restrains the melanogenesis through the blocking mechanism on tyrosinase. 2. It can diminish the senile yellowish brown plaque, also effective for lentigines diminishing. 3. It can evidently diminish the pigmentation cause by ultra-violet radiation. 4. It can improve the metabolism of sunburn skin caused by radiation.

APPLICATION :Recommendatory amount of usage: 1-10%